Viewers loved to hate Young's character, jilted first lady Mellie Grant, so much that she was bumped up to series regular during season three. Young, who won a Critics Choice Television Award for the role, got her start on Broadway but quickly became a mainstay on network television on such shows as Dirty Sexy Money and Peacemakers. She first worked with Rhimes as a guest star on Grey's Anatomy. The actress also has a long list of film credits, including We Were Soldiers and Mission: Impossible III.
(Photos: Courtesy of ABC; Frederick M. Brown/Getty Images)