Jennifer Lopez' "Ain't It Funny (Murder Remix)" and Craig Mack's "Flava in Ya Ear"
As Jennifer Lopez was transitioning into "J. Lo," Ja Rule orchestrated a sampling of Craig Mack's "Flava in Ya Ear" for the Murder mix of her song "Ain't It Funny." Their collab took the top spot of the Hot 100 in 2002, and the original remains sealed in history as the track — along with its remix — that earned Mack a Grammy nod in '95 and helped launch the careers of the Notorious B.I.G. and Busta Rhymes.
(Photos from left: Michael Buckner/Getty Images for Fight Night, Shareif Ziyadat/FilmMagic)