50 Cent loves to make fun of people on Instagram. From Diddy to Rick Ross, Fif has no chill on whoever he is going after. For some reason, Ja Rule has become his new target, after years and years of turmoil.

Last night during Drake’s performance at OVO Fest, Ja Rule chimed in about Drizzy versus Meek when several fans on Twitter were comparing it to Ja’s epic back and forth with 50.

“If y'all wanna compare #meekvsdrake to 50vsRule I'm gonna need one of these ni**as to get stabbed or shot!!!,” he wrote. “All jokes aside I don't wanna see those guys get hurt I like both of them keep it on wax but stop comparing it to other beefs...”

Of course, 50 saw the pandemonium Drake was creating with playing “Back to Back” live, which made him say on Instagram, “Is that me,nah I'm not light skinned. What the f**k is going on. Smh LMAO this guy been watching me close."

Now, 50 seems to be in a “beefing” mode cause he’s clapped back at Ja for what he said on Power 105. Last year, Ja released a tell-all book called Unruly: The Highs and Lows of Being a Man, where he claims he beat 50 up back in the day with a baseball bat.

"50 tried to swing on me, but i dipped, then I hit him with the baby Louisville Slugger. Bam! I dropped the bat. I pulled the shirt over his head," he said at the time. "I started catching him left, right, uppercut...We proceeded to whip his a**. I was putting in my work. 50 was crunched in the corner. I slammed the big Tannoy speaker down on him."

Read 50’s response, below. Can these two just not talk to each other anymore?

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(Photos from Left: Noam Galai/Getty Images, Stephen Lovekin/Getty Images)