They definitely had their share of dustups through the years.
But the three NBA championships that they won in a row with the Los Angeles Lakers from 2000-02 trumps all.
Upon learning of Kobe Bryant announcing that he'll retire at the end of this season, his former teammate Shaquille O'Neal took to his Twitter account to salute the Black Mamba on an unbelievable career.
It's a poignant message from the Diesel.
This comes after Bryant appeared on The Big Podcast With Shaq in late August and the two had a chance to clear the air over tension they had as Laker teammates, with each legend admitting their own faults in their noted feud and ending it on a positive note.
The love that Bryant received from Shaq is only likely to be reciprocated for Kobe, as his Lakers travel from NBA city to city and players and crowds give him standing ovations as final farewells.
Tuesday night will be particularly special, as the Lakers visit the Philadelphia 76ers, Bryant's hometown team.
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(Photos from left: Kevin Winter/Getty Images, Stephen Dunn/Getty Images)
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