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Watch: Here's How Serena Williams Reacted After Suffering a Shocking Loss in the US Open

Who saw this coming?

Serena Williams's history-making feats have been put on hold.

For the second straight year, Williams suffered a shocking upset in the U.S. Open semifinals, as she lost to No. 10 seed Karolina Pliskova, 6-2, 7-6 (5), in New York City on Thursday night.

The loss keeps her at 22 Grand Slam titles, tied with Steffi Graf and two away from Margaret Court's 24 for the most major championships in women's singles tennis history.

Although Williams injured her left knee earlier in the U.S. Open, she didn't use it as an excuse for the loss.

"I'm not going to sit here and make an excuse," said Williams, 34, as reported by ESPN, during her post-match press conference.

She also wasn't having the notion that she was tired after playing her quarterfinal match on Wednesday.

"My mind was just a little bit everywhere, but it was what it was," Williams said. "Yeah, serious left knee problems. But fatigue had nothing to do with it. If I was tired, I need to find a new career. I definitely was not beat up after my quarterfinal match."

Watch Serena's full press conference below.

And Pliskova's reaction to pulling off the grand upset?

"America probably hates me because I beat Venus and Serena," the 24-year-old said after the match, as she beat both Williams sisters in this same U.S. Open.

Serena will now have to wait until January 2017 to pursue her 23rd Grand Slam title at the Australian Open.

Perhaps that's not such a bad thing, considering it will give her time to heal her injured knee.

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